منابع مشابه
Why endosomes recycle GPCRs
Bowman et al. provide a novel explanation for why activated G protein–coupled receptors (GPCRs) migrate from the cell surface to the endosomes (1). The study indicates that GPCRs that have moved to certain locations on endosomes activate specifi c genes—and thus presumably induce different cellular responses. GPCRs help us perceive our surroundings, control our blood pressure, mobilize our immu...
متن کاملOrphan GPCRs and Neuromodulation
Most G protein-coupled receptors (GPCRs) started as orphan GPCRs. Matching them to known neuromodulators led to the elucidation of the broad diversity of the neuroreceptor families. Moreover, orphan GPCRs have also been used as targets to discover novel neuromodulators. These discoveries have had profound impact on our understanding of brain function. Here, I present an overview of how some of ...
متن کاملNeuropeptide GPCRs in Neuroendocrinology
G protein-coupled receptors (GPCRs) represent the single largest family of plasma membrane receptors, encompassing about 860 members in humans. During the last decades, considerable progress has been made regarding the biochemical identification, signaling mechanisms, allosteric modulation, structural characterization, and pathophysiological implication of GPCRs, which are considered as major t...
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| In Cappadocia, Turkey, an unprecedented mesothelioma epidemic causes 50% of all deaths in three small villages. Initially linked solely to the exposure to a fibrous mineral, erionite, recent studies by scientists from Turkey and the United States have shown that erionite causes mesothelioma mostly in families that are genetically predisposed to mineral fibre carcinogenesis. This manuscript re...
متن کاملMolecular Evolution of Gpcrs
Neuropeptides possessing the Arg-Phe-NH2 (RFamide) motif at their C-termini (designated as RFamide peptides) have been characterized in a variety of animals. Among these, neuropeptide 26RFa (also termed QRFP) is the latest member of the RFamide peptide family to be discovered in the hypothalamus of vertebrates. The neuropeptide 26RFa/QRFP is a 26-amino acid residue peptide that was originally i...
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ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2014
ISSN: 1945-3477
DOI: 10.1038/scibx.2014.1337